| Hazard Information | Back Directory | [Uses]
JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable[1]. | [IC 50]
JNK3: 0.379 nM (IC50); JNK2: 29.4 nM (IC50); JNK1: 82.7 nM (IC50); p38α: 215.8 nM (IC50); GSK-3β: 3889.7 nM (IC50) | [References]
[1] Jun J, et al. Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114917. DOI:10.1016/j.ejmech.2022.114917 |
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