| Identification | Back Directory | [Name]
1-BROMO-2,5-BIS(3-CARBOXY-4-HYDROXYSTYRYL)BENZENE | [CAS]
291766-06-8 | [Synonyms]
BSB
1-BROMO-2,5-BIS(3-CARBOXY-4-HYDROXYSTYRYL)BENZENE
(trans, trans)-1-BroMo-2,5-bis-(3-carboxy-4-hydroxy)styrylbenzene | [Molecular Formula]
C24H17BrO6 | [MOL File]
291766-06-8.mol | [Molecular Weight]
481.292 |
| Chemical Properties | Back Directory | [Boiling point ]
705.5±60.0 °C(Predicted) | [density ]
1.637±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (207.77 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
3.10±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease[1]. | [storage]
4°C, protect from light | [References]
[1] M L Schmidt, et al. The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains. Am J Pathol. 2001 Sep;159(3):937-43. DOI:10.1016/s0002-9440(10)61769-5 |
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