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2918764-57-3

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2918764-57-3 Structure

2918764-57-3 Structure
IdentificationBack Directory
[Name]

Pim-1 kinase inhibitor 10
[CAS]

2918764-57-3
[Synonyms]

Pim-1 kinase inhibitor 10
Hazard InformationBack Directory
[Uses]

Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation[1].
[References]

[1] El-Miligy MMM, et, al. Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2152810. DOI:10.1080/14756366.2022.2152810
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