| Identification | Back Directory | [Name]
IT603) | [CAS]
292168-90-2 | [Synonyms]
IT603)
(E/Z)-IT-603
IT-603
(IT 603
4-Imidazolidinone, 5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo- | [Molecular Formula]
C11H9BrN2O3S | [MDL Number]
MFCD02109025 | [MOL File]
292168-90-2.mol | [Molecular Weight]
329.17 |
| Hazard Information | Back Directory | [Uses]
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an I?Bα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
c-Rel''Reversible: yes | [storage]
Store at -20°C | [References]
[1] Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591. DOI:10.1158/2159-8290.CD-13-0585
[2] Huang X, et al. ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway. Front Immunol. 2025 Jan 9;15:1529226. DOI:10.3389/fimmu.2024.1529226 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|