| Identification | Back Directory | [Name]
2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid hydrochloride | [CAS]
2922283-04-1 | [Synonyms]
(RS)-AMPA hydrochloride
2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid hydrochloride |
| Hazard Information | Back Directory | [Uses]
(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors[1][2]. | [References]
[1] H?sli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. DOI:10.1016/0304-3940(83)90486-x
[2] Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5. DOI:10.1126/science.1699275 |
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