| Chemical Properties | Back Directory | [Boiling point ]
564.6±50.0 °C(predicted) | [density ]
1.155±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Oil | [pka]
7.78±0.40(predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1]. | [in vivo]
SG-094 (90 nmol/kg; every 2-3 days over a 10-day timescale) inhibits hepatocellular carcinoma (HCC) tumor growth in mice[1]. | Animal Model: | C57Bl/6-Tyr mice were injected with RIL175 WT cells[1] | | Dosage: | 90 nmol/kg | | Administration: | Every 2-3 days over a 10-day timescale | | Result: | Inhibited tumor growth.
|
| [References]
[1] Müller M, et, al. Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27. DOI:10.1016/j.chembiol.2021.01.023 |
|
|