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CC-3240 (compound 13) is a molecular glue degrader of CaMKK2 based on CC-8977, with the IC50 of 9 nM[1]. | [References]
[1] Chen Y, et al. Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2). J Med Chem. 2023;66(23):15750-15760. DOI:10.1021/acs.jmedchem.3c01137 |
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