| Identification | More | [Name]
2-Chloro-3-methyl-5-bromopyridine | [CAS]
29241-60-9 | [Synonyms]
2-CHLORO-3-METHYL-5-BROMO PYRIDINE
2-CHLORO-5-BROMO-3-PICOLINE
5-BROMO-2-CHLORO-3-METHYLPYRIDINE
5-BROMO-2-CHLORO-3-PICOLINE
2-Chloro-5-bromo-3-methylpyridine
5-BROMO-2-CHLORO-3-PICOLINE (5-BROMO-2-CHLORO-3-METHYLPYRIDINE)
5-Bromo-2-chloro-3-methylpyridine ,98% | [Molecular Formula]
C6H5BrClN | [MDL Number]
MFCD03095093 | [Molecular Weight]
206.47 | [MOL File]
29241-60-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light beige crystalline powder | [Melting point ]
40-44 °C | [Boiling point ]
78°C/3mmHg(lit.) | [density ]
1.6567 (rough estimate) | [refractive index ]
1.5400 (estimate) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Solid | [pka]
-1?+-.0.10(Predicted) | [color ]
White to Almost white | [Detection Methods]
HPLC | [CAS DataBase Reference]
29241-60-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection . | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light beige crystalline powder | [Synthesis]
Example 11B Synthesis of 5-bromo-2-chloro-3-methylpyridine: The product of Example 11A, 5-bromo-3-methylpyridin-2-one (4.1 g, 22.18 mmol), was dissolved in DMF (40 mL) and phosphoryl chloride (10 g, 65.4 mmol) was added drop-wise at 0 °C. The reaction mixture was heated at 120 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into an ice/water mixture. The mixture was adjusted to alkaline with NH4OH, the precipitate was collected by filtration and the filter cake was washed with ice water. The resulting solid was dissolved in dichloromethane (100 mL), the organic layer was washed with brine and dried with anhydrous MgSO4. The dried solution was filtered through a silica pad and the filtrate was concentrated to give 2-chloro-3-methyl-5-bromopyridine as a white solid (3.48 g, 78% yield). The product was characterized by 1H NMR (CDCl3, 300MHz): δ 2.39 (s, 3H), 7.70 (m, 1H), 8.31 (d, J = 3Hz, 1H). | [References]
[1] Patent: US2002/19388, 2002, A1
[2] Patent: EP1428824, 2004, A1. Location in patent: Page 49 |
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