| Chemical Properties | Back Directory | [Boiling point ]
1010.6±65.0 °C(predicted) | [density ]
0.970±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [solubility ]
Ethanol: 10 mg/ml | [form ]
Liquid | [pka]
14.16±0.20(predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts[1]. | [in vivo]
AA-T3A-C12/siHSP47 LNP (siRNA dose of 5?μg/mouse, i.v., twice weekly for 2 weeks) significantly down-regulates HSP47 expression in fibrotic mice[1].
| Animal Model: | CCl4-induced fibrotic mice[1] | | Dosage: | siRNA dose of 5?μg/mouse | | Administration: | i.v., twice weekly for 2 weeks | | Result: | led to a 65% knockdown of HSP47 (in liver) compared to PBS treatment. |
| [References]
[1] Han X, et al. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nat Commun. 2023 Jan 17;14(1):75. DOI:10.1038/s41467-022-35637-z |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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