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2940858-65-9

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2940858-65-9 Structure

2940858-65-9 Structure
IdentificationBack Directory
[Name]

(S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2
[CAS]

2940858-65-9
[Synonyms]

(S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2
[Molecular Formula]

C26H37N5O4S.ClH
[MOL File]

2940858-65-9.mol
[Molecular Weight]

552.13
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in?PROTAC?technology[1].
[IC 50]

VHL
[References]

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
Spectrum DetailBack Directory
[Spectrum Detail]

(S,R,S)-AHPC-C3-NH2 hydrochloride/VH032-C3-NH2(2940858-65-9)1HNMR
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