| Identification | Back Directory | [Name]
Benzenebutanamide, N-[25-[3,4-bis(phenylmethoxy)phenyl]-3,6,9,12,15,18,21-heptaoxa-24-azapentacos-1-yl]- | [CAS]
2941386-60-1 | [Synonyms]
Benzenebutanamide, N-[25-[3,4-bis(phenylmethoxy)phenyl]-3,6,9,12,15,18,21-heptaoxa-24-azapentacos-1-yl]- | [Molecular Formula]
C47H64N2O10 | [MOL File]
2941386-60-1.mol | [Molecular Weight]
817.02 |
| Chemical Properties | Back Directory | [Boiling point ]
880.9±65.0 °C(predicted) | [density ]
1.126±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
15.60±0.46(predicted) |
| Hazard Information | Back Directory | [Uses]
PBA-1105b is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105b increases the autophagic flux of Ub-conjugated aggregates. PBA-1105b is a drastically longer PEG-based linker than PBA-1105[1]. | [References]
[1] Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904. DOI:10.1038/s41467-022-28520-4 |
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