| Chemical Properties | Back Directory | [Boiling point ]
599.5±50.0 °C(predicted) | [density ]
1.23±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
-1.18±0.20(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-55 is a potent inhibitor of Tubulin Polymerization. Tubulin polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC50 s of 8, 3, 9, 24 and 62 nM, respectively[1]. | [References]
[1] Tan Y, et al. Design, synthesis and biological evaluation of novel dihydroquinolin-4(1H)-one derivatives as novel tubulin polymerization inhibitors. Eur J Med Chem. 2023 Oct 15;262:115881. DOI:10.1016/j.ejmech.2023.115881 |
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