| Chemical Properties | Back Directory | [density ]
1.285±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.364±0.20(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
COP1-ATGL modulator 1 (86) is an orally active modulator for COP1-ATGL axis. COP1-ATGL modulator 1 (86) could increase ATGL protein expression, reduce ATGL ubiquitination and COP1 autoubiquitination, and diminish lipid accumulation in hepatocytes in the nanomolar range[1]. | [References]
[1] Dipayan Sarkar, et al. Discovery and Development of Quinazolinones and Quinazolinediones for Ameliorating Nonalcoholic Fatty Liver Disease (NAFLD) by Modulating COP1-ATGL Axis. J Med Chem. 2023 Dec 28;66(24):16728-16761. DOI:10.1021/acs.jmedchem.3c01431 |
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