| Chemical Properties | Back Directory | [density ]
1.350±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
13.71±0.20(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(R)-SKBG-1 is a covalent inhibitor targeting the RNA binding protein NONO. (R)-SKBG-1 can reduce the expression of androgen receptor (AR) and its splice variants, inhibiting cancer cell proliferation. (R)-SKBG-1 inhibits androgen receptor expression with IC50 of 3.1 μM and 5.5 μM for AR-FL mRNA and AR-V7 mRNA, respectively. (R)-SKBG-1 interferes with the gene regulatory network of cancer cells and inhibits cancer cell growth by stabilizing the interaction between NONO and mRNA. (R)-SKBG-1 can be used in the study of cancers related to NONO dysfunction, such as prostate cancer[1][2][3]. | [Biological Activity]
Cell permeable high affinity ligand of RNA-binding protein NONO; stabilize NONO–RNA interactions and rapidly reduces the expression of transcripts encoding AR and AR variants.
(R)-SKBG-1 is a cell permeable high affinity ligand of RNA-binding protein NONO th at binds to Cys 145 of NONO and stabilize NONO–RNA interactions. (R)-SKBG-1 rapidly and stereoselectively reduces the expression of transcripts encoding the androgen receptor (AR) and its splice variants in prostate cancer cells. | [References]
[1] Kathman SG, et al. Remodeling oncogenic transcriptomes by small molecules targeting NONO. Nat Chem Biol. 2023 Jul;19(7):825-836. DOI:10.1038/s41589-023-01270-0
[2] Takeiwa T, et al. Role of RNA binding proteins of the Drosophila behavior and human splicing (DBHS) family in health and cancer. RNA Biol. 2024 Jan;21(1):1-17. DOI:10.1080/15476286.2024.2332855
[3] Schmeing S, et al. Challenges in Therapeutically Targeting the RNA-Recognition Motif. Wiley Interdiscip Rev RNA. 2024 Nov-Dec;15(6):e1877. DOI:10.1002/wrna.1877 |
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| Company Name: |
cjbscvictory
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| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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