| Identification | Back Directory | [Name]
1-Benzyl-3,5,7-triaza-1-azoniaadamantane bromide | [CAS]
29574-21-8 | [Synonyms]
Roslin 2
Roslin 2 bromide
Roslin 2 >=98% (HPLC)
1-Benzyl-3,5,7-triaza-1-azoniaadamantane bromide
1-Benzyl-1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~] decane bromide
1-(Phenylmethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.1~3,7~]decane bromide
Roslin 2 bromide,anticancer effect,Inhibitor,FAK,Roslin 2,Focal adhesion kinase,Benzylhexamethylenetetramine,PTK2,MDM-2/p53,inhibit,PTK2 protein tyrosine kinase 2,p53 reactivator | [Molecular Formula]
C13H19BrN4 | [MOL File]
29574-21-8.mol | [Molecular Weight]
311.221 |
| Hazard Information | Back Directory | [Uses]
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1]. | [in vivo]
Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo[1]. | [References]
[1] Vita M Golubovskaya, et al. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11;13:342. DOI:10.1186/1471-2407-13-342 |
|
| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|