| Identification | Back Directory | [Name]
O-desmethyl Brinzolamide (hydrochloride) | [CAS]
2967475-56-3 | [Synonyms]
O-desmethyl Brinzolamide (hydrochloride) | [Molecular Formula]
C11H19N3O5S3.ClH | [MOL File]
2967475-56-3.mol | [Molecular Weight]
405.95 |
| Hazard Information | Back Directory | [Uses]
O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV[1]. | [References]
[1] Qinhua Huang, et al. Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure. J Med Chem. 2015 Mar 26;58(6):2821-33. DOI:10.1021/acs.jmedchem.5b00043 |
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