| Identification | Back Directory | [Name]
Benzeneacetonitrile, α-[amino[(2-aminophenyl)thio]methylene]-3-(hydroxy-4-pyridinylmethyl)- | [CAS]
297744-42-4 | [Synonyms]
MEK-IN-4
Benzeneacetonitrile, α-[amino[(2-aminophenyl)thio]methylene]-3-(hydroxy-4-pyridinylmethyl)- | [Molecular Formula]
C21H18N4OS | [MOL File]
297744-42-4.mol | [Molecular Weight]
374.46 |
| Chemical Properties | Back Directory | [Boiling point ]
671.9±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 10mg/mL
methanol: 50mg/mL | [form ]
solid | [pka]
12.38±0.20(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
MEK-IN-4 is a MEK inhibitor. MEK-IN-4 can be used for the research of inflammatory disorders and cancers[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
MEK''Product does not compete with ATP.''Reversible: no''Target IC50: 12 nM against MEK | [References]
[1] Frank W. Hobbs, et al. Amino-thio-acrylonitriles as mek inhibitors. Patent. WO2000056706A1. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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