| Identification | Back Directory | [Name]
Dehydrodiacetovanillone | [CAS]
29799-22-2 | [Synonyms]
Diapocynin
Dehydrodiacetovanillone
Diapocynin >=98% (HPLC)
4′,4′′′-Dihydroxy-5′,5′′′-dimethoxy-3′,3′′′-biacetophenone (8CI)
1,1′-(6,6′-Dihydroxy-5,5′-dimethoxy[1,1′-biphenyl]-3,3′-diyl)bis-ethanone
Ethanone, 1,1'-(6,6'-dihydroxy-5,5'-dimethoxy[1,1'-biphenyl]-3,3'-diyl)bis- | [Molecular Formula]
C18H18O6 | [MDL Number]
MFCD27978380 | [MOL File]
29799-22-2.mol | [Molecular Weight]
330.33 |
| Hazard Information | Back Directory | [Uses]
Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities[1]. | [Preparation]
Obtained by alkaline CuO oxidation of lignin (compound Vn-Vn) named dehydrodiacetovanillone. | [Biochem/physiol Actions]
Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent. Diapocynin attenuates oxidative damage and neuroinflammatory responses in animal model of Parkinson′s disease. Diapocynin reverses deficient motor coordination in LRRK2R1441Gtg mice of PD. | [in vivo]
Diapocynin (300 mg/kg; p.o.; every 12 hours for 72 hours) significantly rescues DFP-induced motor impairment, attenuates epileptiform spiking during the first 72h post-DFP. Diapocynin significantly reduces DFP-induced reactive astrogliosis, neurodegeneration, GP91phox, glutathiolated protein, serum nitrite, or pro-inflammatory cytokines and chemokines such as interleukins (IL) IL-1α, IL-6, IL-2, IL-17A, Leptin, IP-10 in the hippocampus[1]. | Animal Model: | Adult male Sprague-Dawley rats (200 g; 7-8 weeks old) injected with Diisopropylfluorophosphate (DFP)[1] | | Dosage: | 300 mg/kg | | Administration: | p.o.; every 12 hours for 72 hours | | Result: | Significantly rescued DFP-induced motor impairment.
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| [storage]
Store at -20°C | [References]
[1] Marson Putra, et al. Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate-induced long-term neurotoxicity in the rat model. Ann N Y Acad Sci. 2020 Nov;1479(1):75-93. DOI:10.1111/nyas.14314 |
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