| Chemical Properties | Back Directory | [Boiling point ]
671.5±55.0 °C(predicted) | [density ]
1.188±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
7.17±0.40(predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
DYB-03 is an oral active HIF-1α/EZH2 inhibitor. DYB-03 inhibits migration, invasion, and angiogenesis of lung cancer cells and HUVECs in vitro and in vivo. DYB-03 induces apoptosis in 2-ME2- and GSK126-resistant of A549 and H460 cells[1]. | [References]
[1] Wang J, et al. The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy. Adv Sci (Weinh). 2024 Feb;11(7):e2303904. DOI:10.1002/advs.202303904 |
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