| Identification | Back Directory | [Name]
L-Arginine, N2-[4-[[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]amino]-1,4-dioxobutyl]- | [CAS]
2983719-82-8 | [Synonyms]
L-Arginine, N2-[4-[[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]amino]-1,4-dioxobutyl]- | [MOL File]
2983719-82-8.mol | [Molecular Weight]
571.62 |
| Hazard Information | Back Directory | [Uses]
Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC50s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis[1]. | [References]
[1] Zheng L, et al. Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation. J Med Chem. 2023 Dec 14;66(23):16187-16200. DOI:10.1021/acs.jmedchem.3c01572 |
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