| Identification | Back Directory | [Name]
2H-Pyran-2-one, 5,6-dihydro-6-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-, (6R)- | [CAS]
2986647-41-8 | [Synonyms]
2H-Pyran-2-one, 5,6-dihydro-6-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-, (6R)- | [Molecular Formula]
C16H20O3 | [MOL File]
2986647-41-8.mol | [Molecular Weight]
260.33 |
| Hazard Information | Back Directory | [Uses]
CRM1 degrader 1 (1l) is a low toxic chromosome region maintenance 1 (CRM1) degrader. CRM1 is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer agent target. CRM1 degrader 1 induces the apoptosis in gastric carcinoma and selectively inhibits proliferation of gastric cancer[1]. | [References]
[1] Xu HW, et al. A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27. Eur J Med Chem. 2020;206:112708. DOI:10.1016/j.ejmech.2020.112708 |
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