| Chemical Properties | Back Directory | [Boiling point ]
617.129±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.424±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
8.117±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases[1]. | [References]
[1] Abdelrahman Mohamed, et al. Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem. 2022 Aug 22. DOI:10.1021/acs.jmedchem.2c00589 |
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