| Chemical Properties | Back Directory | [Boiling point ]
711.5±60.0 °C(predicted) | [density ]
1.234±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
9.70±0.10(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC50 s of 0.019, 0.017, 0.020 and 0.044 μM, respectively[1]. | [References]
[1] Xiang-Jing Fu, et al. Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities, European Journal of Medicinal Chemistry, Volume 262, 2023, 115883. |
|
|