| Identification | Back Directory | [Name]
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride | [CAS]
300827-87-6 | [Synonyms]
D2069
Desvenlafaxine HCl
Venlafaxine Impurity 16
Desvenlafaxine hydrochloride
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride | [Molecular Formula]
C16H25NO2HCl | [MDL Number]
MFCD11045287 | [MOL File]
300827-87-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
>75°C (dec.) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >20mg/mL | [form ]
powder | [color ]
white to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression. | [Uses]
Desvenlafaxine Hydrochloride is a major active metabolite of venlafaxine (V120000), which is a slective serotonin noradrenaline reuptake inhibitor and used as an antidepressant. | [Biochem/physiol Actions]
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM. |
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