| Identification | More | [Name]
1-[Cyano-(p-methoxyphenyl)methyl]cyclohexanol | [CAS]
93413-76-4 | [Synonyms]
1-[(1-CYANO)-1-(4-METHOXYPHENYL)METHYL] CYCLOHEXANOL
1-(CYANO-(4-METHOXY PHENYL) METHYL) CYCLOHEXANOL
1-[CYANO-(P-METHOXYPHENYL)METHYL]CYCLOHEXANOL
1-HYDROXYCYCLOHEXYL-4-METHOXY PHENYL ACETONITRILE
alpha-(1-Hydroxycyclohexyl)-4-methoxybenzeneacetonitrile
1-(Hydroxycyclohexyl)-(4-Methoxyphenly)Acetonitrlle
1-[(1-CYANO)-1-(4-METHOXYPHENYL)METHYL]CYCLODEXANOL
1-[Cyno-(4-Methoxyphenyl)Methyl]Cyclohexanol(Vf1)
1-HydroxyCyclohexyl-4-MethoxyPhenylAcetonitrile(ForVenlafaxineHcl)
forVenlafaxine
Intermediate of Venlafaxine
1-[Cyano-(4-Methoxyphenyl)Meth
1-(hydroxycyclohexyl)-(4-methoxyphenyl)acetonitrile (intermediate of venlafaxine)
1-hydroxy cyclohexyl-4-methoxy phenyl acetonitrile (intermediate of venlafaxine hcl)
1-[CYANO-(4-METHOXYPHENYL)METHYL]CYCLOHEXANOL[FOR VENLAFAXINE HCL]
1-(cyclohexanol)-(4methoxyphenyl)acetonitrile | [EINECS(EC#)]
618-945-8 | [Molecular Formula]
C15H19NO2 | [MDL Number]
MFCD06658142 | [Molecular Weight]
245.32 | [MOL File]
93413-76-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White Powder | [Melting point ]
121-123°C | [Boiling point ]
410.1±25.0 °C(Predicted) | [density ]
1.142±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
13.80±0.20(Predicted) | [color ]
White to Almost white | [Usage]
An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine | [CAS DataBase Reference]
93413-76-4(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Synthesis]
A mixture of p-methoxyphenylacetonitrile 36 (100 g, 0.68 mol), 10%
aqueous NaOH solution (100 ml, 0.25 mol) and TBAHSO4 (5 g, 0.014
mol) was stirred at room temperature for 30 minutes. A dark red colour
appeared. To this was added cyclohexanone 34 (67 g, 0.680 mol) in
small portions at 0 ºC, with vigorous stirring, in such a way that
temperature should not rise above 10 ºC. A white solid was formed
within 30 minutes to one hour. The solid was crushed and the reaction mixture was further
stirred vigorously at room temperature for one more hour. The solid was filtered, washed
with water till neutral to pH paper and air-dried. Crystallization from ethyl acetatepetroleum ether (500:350, v/v) gave a bright white solid (161.66 g).
 |
| Hazard Information | Back Directory | [Chemical Properties]
White Powder | [Uses]
An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine |
|
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