| Identification | More | [Name]
1-METHYL-2-FORMYLBENZIMIDAZOLE | [CAS]
3012-80-4 | [Synonyms]
1-METHYL-1H-BENZIMIDAZOLE-2-CARBALDEHYDE
1-METHYL-1H-BENZIMIDAZOLE-2-CARBOXALDEHYDE
1-METHYL-1H-BENZOIMIDAZOLE-2-CARBALDEHYDE
1-METHYL-2-FORMYLBENZIMIDAZOLE
AKOS BC-1517
TIMTEC-BB SBB010051
ZERENEX EZX001709
1-methylbenzimidazole-2-carboxaldehyde
1-Methyl-2-formylbenzimidazole 97%
1H-Benzimidazole-2-carboxaldehyde,1-methyl-(9CI)
1-METHYLBENZIMDAZOLE-2-CARBOXALDEHYDE, 99+%
1-Methylbenzimidazole-2-carboxaldehyde, 99+%
1-Methyl-2-formylbenzimidazole, 99+%
1-methyl-1H-benzo[d]imidazole-2-carbaldehyde
1-Methylbenzimidazole-2-carboxaldehyde, 98+% | [Molecular Formula]
C9H8N2O | [MDL Number]
MFCD00142655 | [Molecular Weight]
160.17 | [MOL File]
3012-80-4.mol |
| Chemical Properties | Back Directory | [Appearance]
OFF-WHITE TO LIGHT BEIGE CRYSTALLINE POWDER | [Melting point ]
114-116 °C | [Boiling point ]
286.07°C (rough estimate) | [density ]
1.1846 (rough estimate) | [refractive index ]
1.5570 (estimate) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Crystalline Powder | [pka]
3?+-.0.10(Predicted) | [color ]
Off-white to light beige | [Sensitive ]
Air Sensitive | [CAS DataBase Reference]
3012-80-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
OFF-WHITE TO LIGHT BEIGE CRYSTALLINE POWDER | [Uses]
1-Methyl-1H-benzimidazole-2-carboxaldehyde is a reagent used for the synthesis of dual protein kinase B alpha (AKT) and nuclear factor kappa-light-chain-enchancer of activated B cells (NF-κB) against melanoma. | [Synthesis]
General procedure for the synthesis of 1-methyl-2-formylbenzimidazole from N-methylbenzimidazole and 2,2-diethoxyacetic acid: N-methylbenzimidazole (0.10 mmol, 1.0 eq.), ammonium persulfate (0.30 mmol, 3.0 eq.), and Cs2CO3 (0.20 mmol, 2.0 eq.) were placed in a dry glass tube. Subsequently, anhydrous DMSO (1 mL) and 2,2-diethoxyacetic acid (0.7 mmol) were added to the tube via syringe under nitrogen protection. The reaction mixture was stirred for 24 h at room temperature using 15 W blue LED strip irradiation. After completion of the reaction, the reaction was quenched by the addition of 1.2 mL of 3.0 M HCl and stirring was continued for 20 hours. Afterwards, the pH was adjusted with saturated Na2CO3 solution and extracted with CH2Cl2. The organic layers were combined, washed with brine and dried over anhydrous Na2SO4. Finally, the target product 1-methyl-2-formylbenzimidazole was purified by rapid chromatography on silica gel, using petroleum ether and ethyl acetate as eluents, and the corresponding yield was calculated. | [References]
[1] Synlett, 2018, vol. 29, # 14, p. 1881 - 1886 |
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