| Identification | Back Directory | [Name]
Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-(4-aminobutyl)-6-(2,5-difluorophenyl)-2-(methylamino)- | [CAS]
3027761-24-3 | [Synonyms]
Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-(4-aminobutyl)-6-(2,5-difluorophenyl)-2-(methylamino)- | [Molecular Formula]
C18H19F2N5O | [MOL File]
3027761-24-3.mol | [Molecular Weight]
359.37 |
| Chemical Properties | Back Directory | [Boiling point ]
537.9±60.0 °C(predicted) | [density ]
1.341±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
10.28±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells[1]. | [References]
[1] Marcel Rak, et al. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. European Journal of Medicinal Chemistry. Volume 254, 5 June 2023, 115347. |
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