| Chemical Properties | Back Directory | [density ]
1.63±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml) | [form ]
solid | [pka]
4.86±0.20(Predicted) | [color ]
Orange-red | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
EPAC 5376753 (302826-61-5) is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2 | [Uses]
EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 μM in Swiss 3T3 cells. | [storage]
Store at -20°C | [References]
1) Brown et al. (2014), Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors; J. Biol. Chem., 289 29148
2) Parnell et al. (2015), The future of EPAC-targeted therapies: agonism versus antagonism; Trends Pharmacol. Sci., 36 203 |
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