ChemicalBook--->CAS DataBase List--->3031072-69-9

3031072-69-9

Request For Quotation

Directory

Chemical Properties

Hazard Information

3031072-69-9 Structure

3031072-69-9 Structure

Identification	Back Directory
[Name] YZL-51N
[CAS] 3031072-69-9
[Synonyms] YZL-51N
[Molecular Formula] C17H14O7
[MOL File] 3031072-69-9.mol
[Molecular Weight] 330.29

Chemical Properties	Back Directory
[Boiling point ] 636.089±55.00 °C(Press: 760.00 Torr)(predicted)
[density ] 1.478±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 7.362±0.20(predicted)

Hazard Information	Back Directory
[Uses] YZL-51N is a selective SIRT7 inhibitor with IC50 value of 12.71 μM. YZL-51N disrupts SIRT7 enzyme activity by occupying the NAD+ binding pocket, thereby weakening DNA damage repair and inhibiting cancer cell survival. YZL-51N possesses anti-tumor activity and can be used in cancer research[1].
[in vivo] YZL-51N (15 mg/kg, subcutaneous injection) can reduce tumor volume in HCT116 xenograft model^[1].
[IC 50] SIRT7: 12.71 μM (IC₅₀)
[References] [1] Kang TS, et al. YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair. iScience. 2024 May 16;27(6):110014. DOI:10.1016/j.isci.2024.110014

3031072-69-9 suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

Tags:3031072-69-9 Related Product Information