| Identification | Back Directory | [Name]
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID | [CAS]
303175-44-2 | [Synonyms]
2-(2-CHLORO-4-IODOPHENYLAMINO)-3,4-DIFLUOROBENZOIC ACID
3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid | [Molecular Formula]
C13H7ClF2INO2 | [MDL Number]
MFCD09840238 | [MOL File]
303175-44-2.mol | [Molecular Weight]
409.554 |
| Chemical Properties | Back Directory | [Appearance]
Light-Brown Solid | [Melting point ]
230-231 °C | [Boiling point ]
401.5±45.0 °C(Predicted) | [density ]
1.946±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.25±0.36(Predicted) | [color ]
White to Brown | [InChI]
1S/C13H7ClF2INO2/c14-8-5-6(17)1-4-10(8)18-12-7(13(19)20)2-3-9(15)11(12)16/h1-5,18H,(H,19,20) | [InChIKey]
XCNBGWKQXRQKSA-UHFFFAOYSA-N | [SMILES]
O=C(C1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)O |
| Hazard Information | Back Directory | [Chemical Properties]
Light-Brown Solid | [Uses]
2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoic Acid (cas# 303175-44-2) is a compound useful in organic synthesis. | [Biological Activity]
ATR-002a derivate of CI-1040is a cell penetrantpotent and specific inhibitor of the Raf/MEK/ERK pathway. ATR-002 exhibits strong anti-influenza and anti-SARS-CoV-2 activity. It impairs the influenzas and SARS-CoV-2 viruses induced expression of pro-inflammatory cytokines. | [in vivo]
Zapnometinib (8.4-75 mg/kg/day; three times a day p.o.) reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1].
Zapnometinib (150 mg/kg) exhibits AUC values of 860.02 and 1953.68 μg h/mL in mice by i.v. or oral route, respectively[1]. | Animal Model: | Female C57BL/6 mice (8 weeks; 21-24 g) were infected with H1N1pdm09[1] | | Dosage: | 8.4, 25, 75 mg/kg/day (2.8, 8.4, 25 mg/kg)
| | Administration: | P.o. three times a day | | Result: | Significantly reduced the virus titer at the dose of either 75 mg/kg/day or 25 mg/kg/day.
|
| [IC 50]
MEK: 5.7 nM (IC50) | [storage]
4°C, protect from light |
|
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Alfa Chemistry
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Energy Chemical
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