| Chemical Properties | Back Directory | [Boiling point ]
1146.322±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
0.940±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Ethanol: Soluble: = 10 mg/ml | [pka]
14.423±0.20(predicted) |
| Hazard Information | Back Directory | [Description]
E10i-494 is an ionizable cationic branched endosomal disruptor (BEND) lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro.1 LNPs containing E10i-494 and encapsulating mCherry or luciferase mRNA induce mCherry or luciferase expression in T cells.WARNING This product is not for human or veterinary use. | [References]
[1] PADILLA M S, MRKSICH K, WANG Y, et al. Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering[J]. Nature Communications, 2025, 2 1. DOI: 10.1038/s41467-024-55137-6 |
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