3032196-88-3

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3032196-88-3 Structure

Chemical Properties	Back Directory
[Boiling point ] 414.7±45.0 °C(predicted)
[density ] 1.25±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] -2.10±0.40(predicted)

Hazard Information	Back Directory
[Uses] TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1].
[IC 50] TEAD1: 8.7 nM (IC₅₀); TEAD2: 3.4 nM (IC₅₀); TEAD3: 5.6 nM (IC₅₀)
[References] [1] Henry William, et al. Yap/taz-tead oncoproteins inhibitors.WO2024059317A1.2023-09-15

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