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3032646-96-8

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3032646-96-8 Structure

3032646-96-8 Structure
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[Name]

QC-182
[CAS]

3032646-96-8
[Synonyms]

QC-182
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[Uses]

QC-182 is a potent PROTAC degrader of p300/CBP. QC-182 reduces p300 protein in the SK-HEP-1 cells (DC50 = 93nM). QC-182 potently and effectively inhibits cell growth in the SK-HEP-1 and JHH7 cell lines with IC50 values of 0.733 and 0.477 μM, respectively. QC-182 can be used for the research of hepatocellular carcinoma (HCC)[1].
[References]

[1] Chang Q, et al. Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma. J Med Chem. 2024 Feb 22;67(4):2466-2486. DOI:10.1021/acs.jmedchem.3c01468
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3032646-96-8 2222941-37-7 16611-84-0 2446928-30-7 2365172-42-3 1818885-28-7