| Chemical Properties | Back Directory | [Boiling point ]
658.733±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.228±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 10 mg/mlPBS (pH 7.2): Slightly |
| Hazard Information | Back Directory | [Uses]
ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562). ATM Inhibitor-7 combines with CPT-11 shows antitumor activity[1]. | [in vivo]
ATM Inhibitor-7 (5 mg/kg; i.p.; once daily for 23 days) combines with CPT-11 (5 mg/kg, i.p.; once a week) shows antitumor activity in mice[1]. | Animal Model: | Female nude mice (SW620 tumor xenograft model)[1] | | Dosage: | 5 mg/kg; CPT-11 (5 mg/kg, i.p.; once a week) | | Administration: | I.p.; once daily for 23 days | | Result: | Increased the antitumor activity of CPT-11. |
| [IC 50]
ATM: 1.0 nM (IC50) | [References]
[1] Shiyu Zhang, et al. Discovery of [1,2,3]Triazolo[4,5-c]quinoline Derivatives as a New Class of Ataxia-Telangiectasia Mutated Kinase Inhibitors. ACS Med. Chem. Lett. 2023. |
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