| Chemical Properties | Back Directory | [Boiling point ]
527.642±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.253±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml | [pka]
9.501±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative[1]. | [References]
[1] Nicoletta Brindani, et al. Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Apr 27;66(8):5981-6001. DOI:10.1021/acs.jmedchem.3c00276 |
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