| Identification | Back Directory | [Name]
CXCR4 antagonist 10 | [CAS]
3056005-98-9 | [Synonyms]
CXCR4 antagonist 10
1H-Pyrazole-4-carboxylic acid, 1-[5-[(3-methoxyphenyl)methoxy]-2-pyrimidinyl]-, ethyl ester | [Molecular Formula]
C18H18N4O4 | [MOL File]
3056005-98-9.mol | [Molecular Weight]
354.36 |
| Chemical Properties | Back Directory | [Boiling point ]
568.202±58.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.281±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
-1.652±0.42(predicted) |
| Hazard Information | Back Directory | [Uses]
ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of a DNA N6-methyladenine demethylase ALKBH1 inhibitor that significantly increases the abundance of 6mA in cells and upregulates the AMPK signaling pathway, thereby inhibiting the viability of gastric cancer cells. ALKBH1-IN-4 prodrug exhibits excellent cellular activity and favorable metabolic exposure in vivo, and holds promise for research in gastric cancer[1]. | [References]
[1] Li F, et al. Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity. J Med Chem. 2024 Sep 12;67(17):15456-15475. DOI:10.1021/acs.jmedchem.4c01072 |
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