| Identification | More | [Name]
L-Aspartic acid 4-tert-butyl ester | [CAS]
3057-74-7 | [Synonyms]
ASPARTIC ACID BETA T-BUTYL ESTER MONOHYDRATE
ASPARTIC ACID(OTBU)
H-ASP(OBUT)-OH
H-ASP(OTBU)-OH
H-L-ASP(OTBU)-OH
H-L-ASP(TBU)-OH H2O
L-ASPARTIC ACID 4-TERT-BUTYL ESTER
L-ASPARTIC ACID BETA-T-BUTYL ESTER
L-ASPARTIC ACID BETA-T-BUTYL ESTER MONOHYDRATE
L-ASPARTIC ACID B-TERT-BUTYL ESTER
4-tert-butyl hydrogen L-aspartate
L-ASPARTIC ACID BETA-TERT-BUTYL ESTER 1-HYDRATE
L-Asp(OtBu)-OH
L-ASPARTIC ACID SS-T-BUTYL ESTER MONOHYDRATE
L-ASPARTIC ACID-B-T-BUTYLESTER
L-ASPARTIC ACID 4-(1,1-DIMETHYLETHYL) ESTER
(2S)-2-Amino-3-(tert-butoxycarbonyl)propionic acid
(S)-2-Aminosuccinic acid 4-tert-butyl ester
3-Boc-L-Ala-OH
Asp(OBut) | [EINECS(EC#)]
221-292-8 | [Molecular Formula]
C8H15NO4 | [MDL Number]
MFCD00038577 | [Molecular Weight]
189.21 | [MOL File]
3057-74-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
220°C (dec.) | [Boiling point ]
318.7±37.0 °C(Predicted) | [density ]
1.162±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Methanol (Slightly), Water (Slightly, Sonicated) | [form ]
Solid | [pka]
2.19±0.23(Predicted) | [color ]
White to Off-White | [Optical Rotation]
[α]20/D 9±2°, c = 2% in methanol: water (4:1) | [BRN ]
4671089 | [Stability:]
Hygroscopic | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C8H15NO4/c1-8(2,3)13-6(10)4-5(9)7(11)12/h5H,4,9H2,1-3H3,(H,11,12)/t5-/m0/s1 | [InChIKey]
MXWMFBYWXMXRPD-YFKPBYRVSA-N | [SMILES]
C(O)(=O)[C@H](CC(OC(C)(C)C)=O)N | [CAS DataBase Reference]
3057-74-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
36/37/38 | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29225090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
L-Aspartic acid 4-tert-butyl ester is a protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
In a 3000 mL three-necked bottle, add 1000 mL of dichloromethane, cool down to -5°C, add 344 g of anhydrous p-toluenesulfonic acid and 133 g of aspartic acid, pass through 448 g of isobutene, and maintain the reaction at -5°C for 50 hours; and then adj |
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