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306959-01-3

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306959-01-3 Structure

306959-01-3 Structure
IdentificationBack Directory
[Name]

N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
[CAS]

306959-01-3
[Synonyms]

MYLS22
N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
1H-Thieno[2,3-c]pyrazole-5-carboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-methyl-1-phenyl-
[Molecular Formula]

C24H21N5O2S
[MDL Number]

MFCD01062681
[MOL File]

306959-01-3.mol
[Molecular Weight]

443.52
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 83.33 mg/mL (187.88 mM)
[form ]

Solid
[color ]

Off-white to yellow
Safety DataBack Directory
[Symbol(GHS) ]

Corrosion (GHS05)Flame (GHS02)
GHS05,GHS02
[Signal word ]

Danger
[Hazard statements ]

H314-H226
[Precautionary statements ]

P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405
Spectrum DetailBack Directory
[Spectrum Detail]

N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide(306959-01-3)1HNMR
Hazard InformationBack Directory
[Biological Activity]

MYLS22 is a first-in-class, selective optic atrophy 1 (OPA1) inhibitor. It can target endothelial cell OPA1 to reduce tumor growth and inhibit angiogenesis by affecting NFkB activity and angiogenic gene expression.
[in vivo]

MYLS22 (10 mg/kg/die; peritumoral injection; every 2 days for 14 days) causes the tumor growth curtailed mice.

Animal Model: 6-week-old C57BL6/J mice with B16F10 melanomas
Dosage: 10 mg/kg/die
Administration: Peritumoral injection; every 2 days for 14 days
Result: Caused the tumor growth curtailed.
[target]

OPA1

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