ChemicalBook--->CAS DataBase List--->307983-31-9

307983-31-9

307983-31-9 Structure

307983-31-9 Structure
IdentificationBack Directory
[Name]

GRA Ex-25
[CAS]

307983-31-9
[Synonyms]

GRA Ex-25
GRA Ex-25 USP/EP/BP
β-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-
B-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-
[Molecular Formula]

C29H36F3N3O5
[MDL Number]

MFCD11977277
[MOL File]

307983-31-9.mol
[Molecular Weight]

563.61
Chemical PropertiesBack Directory
[Melting point ]

152-154 °C
[Boiling point ]

726.3±60.0 °C(Predicted)
[density ]

1.28±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[solubility ]

DMF:25.0(Max Conc. mg/mL);44.36(Max Conc. mM)
DMSO:28.5(Max Conc. mg/mL);50.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);17.74(Max Conc. mM)
[form ]

A crystalline solid
[pka]

4.29±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.
[in vivo]

GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose caused by exogenous administration of glucagon in rat model. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenous administered glucagon, most likely because of the direct inhibition of glucagon stimulated hepatic glucose output[2].

[storage]

Store at -20°C
[References]

[1] Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. DOI:10.1016/j.bmcl.2004.02.056
[2] Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. DOI:10.1021/jm058026u
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