| Identification | More | [Name]
L-CYSTINE DIHYDROCHLORIDE | [CAS]
30925-07-6 | [Synonyms]
(H-CYS-OH)2 2HCL
(H-CYS-OH)2 HCL
L-(-)-CYSTINE DIHYDROCHLORIDE
L-CYSTINE DIHYDROCHLORIDE
L-Cystine HCl Monohydrate
L-Cystine dihydrochloride, non-animal source, cell culture tested
Cystine2HCl,L-
L-CYSTINE DIHYDROCHLORIDE SALT
L-CYSTINE DIHYDROCHLORIDE SYNTHETICALLY DERIVED
Cystine Dihydrochloride, L- | [EINECS(EC#)]
250-391-9 | [Molecular Formula]
C6H14Cl2N2O4S2 | [MDL Number]
MFCD00070399 | [Molecular Weight]
313.22 | [MOL File]
30925-07-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
228-232℃ | [alpha ]
[α]D20 -165～-175° (c=1, dil. HCl) | [density ]
1.518[at 20℃] | [vapor pressure ]
0Pa at 20℃ | [storage temp. ]
Store at RT. | [solubility ]
0.5 M HCl: 50 mg/mL
| [form ]
Powder | [color ]
White to Pale Yellow | [Odor]
odorless | [biological source]
synthetic | [Optical Rotation]
[α]20/D -174 to -164 °, c =2 in 1 M HCl | [Water Solubility ]
Soluble in hydrochloric acid. (0.5 M HCl: 50 mg/mL) Soluble in water. | [InChI]
InChI=1/C6H12N2O4S2.ClH/c7-3(5(9)10)1-13-14-2-4(8)6(11)12;/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12);1H/t3-,4-;/s3 | [InChIKey]
IOCJWNPYGRVHLN-QYDODFSFNA-N | [SMILES]
[C@@H](N)(C(=O)O)CSSC[C@H](N)C(=O)O.Cl |&1:0,9,r| | [LogP]
-5.08 at 25℃ | [CAS DataBase Reference]
30925-07-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29309090 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Eye Dam. 1
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Uses]
L-Cystine is a sulfur containing non-essential amino acid. It is used as a cell culture media component and raw material in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Cystine dihydrochloride is a modified version of L-Cystine with improved solubility. | [Flammability and Explosibility]
Notclassified | [Biochem/physiol Actions]
L-Cystine is a natural proteinogenic amino acid sulfide dimer of L-cysteine. L-cystine is used as a cell culture supplement. L-cystine is also used to characterize and identify specific amino acid transport systems in cells such as system system Xc(─) . | [in vivo]
L-Cystine dihydrochloride (280 mg/kg, p.o., 11 days) administrated with L-theanine (HY-15121) enhances antigen-specific IgG production partly through augmentation of glutathione (GSH) levels and T helper 2 (Th2)-mediated responses in mice[2].
L-Cystine dihydrochloride (200 mg/kg, p.o., 11 days) administrated with L-theanine (HY-15121) (80 mg/kg, p.o., 11 days) significantly decreases the serum IL-10/IFN-γ ratio 6 hours after DNP-KLH antigenic stimulation, but increases the serum IL-10/IFN-γ ratio 24 hours after DNP-KLH antigenic stimulation in mice[2]. | Animal Model: | Nine-week-old female BALB/c mice[2] | | Dosage: | 140, 280 and 560 mg/kg | | Administration: | p.o. administration for 11 days | | Result: | Increased IgG and IgM antibody production administrated with L-theanine (HY-15121) after DNP-dextran and DNP-KLH antigenic stimulation in mice. |
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