| Identification | More | [Name]
4-Amino-2,5-dimethylphenol | [CAS]
3096-71-7 | [Synonyms]
4-AMINO-2,5-DIMETHYLPHENOL
4-AMINO-2,5-XYLENOL
4-AMINO-2,5-DIMETHYLPHENOL, TECH.
2,5-Dimethyl-4-aminophenol | [EINECS(EC#)]
221-449-0 | [Molecular Formula]
C8H11NO | [MDL Number]
MFCD00007873 | [Molecular Weight]
137.18 | [MOL File]
3096-71-7.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
242-243 °C (lit.) | [Boiling point ]
288.4±28.0 °C(Predicted) | [density ]
1.118±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Powder | [pka]
pK1: 5.28(+1);pK2: 10.40(0) (25°C) | [color ]
White to beige | [Stability:]
Stable. Incompatible with acids, chloroformates, acid anhydrides, acid chlorides, strong oxidizing agents. | [CAS DataBase Reference]
3096-71-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29222990 |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Uses]
4-Amino-2,5-dimethylphenol may be used in chemical synthesis studies. | [Synthesis]
GENERAL METHOD: A mixture of p-benzoquinone monoxime (1.26 mmol), SnCl2 (0.72 g, 3.80 mmol), 20 mL of CH2Cl2, and 0.2 mL of concentrated HCl was heated and refluxed for 16 hours. After completion of the reaction, CH2Cl2 was removed by distillation under reduced pressure. the residue was dissolved in ethyl acetate and washed with saturated aqueous NaHCO3. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 4-amino-2,5-dimethylphenol as a solid product. | [References]
[1] Tetrahedron, 2014, vol. 70, # 39, p. 6963 - 6973
[2] Chemische Berichte, 1885, vol. 18, p. 570
[3] Chemische Berichte, 1887, vol. 20, p. 979
[4] Journal of the American Chemical Society, 1917, vol. 39, p. 2190
[5] Journal of the American Chemical Society, 2016, vol. 138, # 16, p. 5202 - 5205 |
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