| Identification | Back Directory | [Name]
2-naphthoylethyltrimethylammonium | [CAS]
31059-54-8 | [Synonyms]
Α-NETA
β-NETA
2-naphthoylethyltrimethylammonium
2-(beta-Naphthoyl)ethyltrimethylammonium iodide
2-Dimethylaminoethyl 2-naphthyl ketone methiodide
trimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium:iodide | [Molecular Formula]
C16H20NO.I | [MOL File]
31059-54-8.mol |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
DMSO: 3mg/ml; Methanol: Soluble | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture. | [Uses]
Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.[Cayman Chemical] | [IC 50]
AChE | [storage]
Store at -20°C, protect from light, stored under nitrogen | [References]
[1] B V SASTRY. 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase.[J]. Journal of Pharmacology and Experimental Therapeutics, 1988, 245 1: 72-80.
[2] B.V. RAMA SASTRY. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(α-naphthoyl)ethyltrimethylammonium and related compounds[J]. Pharmacological research communications, 1988, 20 9: Pages 751-771. DOI: 10.1016/s0031-6989(88)80715-x
[3] B.M. EATON S. R S. Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells[J]. Placenta, 1998, 19 8: Pages 663-669. DOI: 10.1016/s0143-4004(98)90028-5
[4] DEBORAH A SAWATZKY. Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells.[J]. American journal of physiology. Lung cellular and molecular physiology, 2003, 285 6: L1296-304. DOI: 10.1152/ajplung.00107.2003 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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