| Identification | Back Directory | [Name]
Benzamide, N-[2-(1-naphthalenyl)-1-[[(phenylmethyl)amino]carbonyl]ethenyl]- | [CAS]
313957-41-4 | [Synonyms]
Benzamide, N-[2-(1-naphthalenyl)-1-[[(phenylmethyl)amino]carbonyl]ethenyl]- | [Molecular Formula]
C27H22N2O2 | [MOL File]
313957-41-4.mol | [Molecular Weight]
406.48 |
| Chemical Properties | Back Directory | [Boiling point ]
731.0±60.0 °C(predicted) | [density ]
1.223±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
10.76±0.46(predicted) |
| Hazard Information | Back Directory | [Uses]
PAR-2 antagonist 1 (Compound 9a) is a protease-activated receptor 2 (PAR2) antagonist with an IC50 value of 0.9 μM. PAR-2 antagonist 1 can effectively inhibit the proliferation and migration of breast cancer cells[1]. | [References]
[1] Kim T, et al. Discovery of Protease-activated receptor 2 antagonists derived from phenylalanine for the treatment of breast cancer. Bioorg Chem. 2024 Sep;150:107496. DOI:10.1016/j.bioorg.2024.107496 |
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