| Identification | More | [Name]
2-Chloro-4,6-dimethoxy-1,3,5-triazine | [CAS]
3140-73-6 | [Synonyms]
2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE
AKOS 89995
CDMT
Chlorodimethoxytriazine
2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE, 9 7%
2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (CDMT)
2-CHLORO-4,6-DIMETHOXY-TRIAZINE
2-CHLORO 4,6-DIMETHOX 1,3,5-TRIAZINE
4-CHLORO-2,6-DIMETHOXY-1,3.5-TRIAZINE
1,3,5-Triazine, 2-chloro-4,6-dimethoxy-
2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE 98%
2,4-Dimethoxy-6-chloro-1,3,5-triazine
2,4-Dimethoxy-6-chloro-s-triazine | [EINECS(EC#)]
221-541-0 | [Molecular Formula]
C5H6ClN3O2 | [MDL Number]
MFCD00075607 | [Molecular Weight]
175.57 | [MOL File]
3140-73-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to almost white crystalline powder | [Melting point ]
71-74 °C (lit.) | [Boiling point ]
99-100 °C (1 mmHg)
| [density ]
1.7917 (rough estimate) | [vapor pressure ]
5.8Pa at 25℃ | [refractive index ]
1.5870 (estimate) | [Fp ]
99-100°C/1mm | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform, Methanol | [form ]
Crystalline Powder | [pka]
0.33±0.10(Predicted) | [color ]
White to almost white | [Water Solubility ]
insoluble | [Detection Methods]
HPLC | [BRN ]
148988 | [InChI]
1S/C5H6ClN3O2/c1-10-4-7-3(6)8-5(9-4)11-2/h1-2H3 | [InChIKey]
GPIQOFWTZXXOOV-UHFFFAOYSA-N | [SMILES]
COc1nc(Cl)nc(OC)n1 | [LogP]
2.105 at 25℃ | [CAS DataBase Reference]
3140-73-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S36:Wear suitable protective clothing . | [RIDADR ]
UN3077 | [WGK Germany ]
3
| [REACH Registrations]
Active | [HS Code ]
29336900 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Aquatic Chronic 2
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
white to almost white crystalline powder | [Uses]
2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines. | [General Description]
2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. | [Synthesis]
A preparation method of 2-chloro-4,6-dimethoxy-1,3,5-triazine comprises the following steps: using cyanuric chloride and sodium methoxide solid as reaction raw materials and N, N-dimethylformamide as a reaction solvent, gradually heating to obtain a 2-chloro-4,6-dimethoxy-1,3,5-triazine crude product, and finally, recrystallizing with heptane for purification. The reaction temperature is controlled to prepare the product, and the yield is up to 91%.
| [References]
[1] Molecules, 2016, vol. 21, # 6,
[2] Patent: WO2016/103185, 2016, A2. Location in patent: Page/Page column 34
[3] Journal of Materials Chemistry C, 2018, vol. 6, # 13, p. 3288 - 3297
[4] Patent: CN103497211, 2016, B. Location in patent: Paragraph 0113
[5] Synthetic Communications, 1996, vol. 26, # 18, p. 3491 - 3494 |
| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
2-Chloro-4,6-dimethoxy-1,3,5-triazine, 98%(3140-73-6) | [Alfa Aesar]
2-Chloro-4,6-dimethoxy-1,3,5-triazine, 98%(3140-73-6) | [Sigma Aldrich]
3140-73-6(sigmaaldrich) | [TCI AMERICA]
2-Chloro-4,6-dimethoxy-1,3,5-triazine,>97.0%(LC)(T)(3140-73-6) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
|