| Identification | Back Directory | [Name]
IDD388
(IDD 388) | [CAS]
314297-26-2 | [Synonyms]
IDD388
IDD388
(IDD 388)
Acetic acid, 2-[2-[[[(4-bromo-2-fluorophenyl)methyl]amino]carbonyl]-5-chlorophenoxy]- | [Molecular Formula]
C16H12BrClFNO4 | [MOL File]
314297-26-2.mol | [Molecular Weight]
416.63 |
| Chemical Properties | Back Directory | [Boiling point ]
574.5±50.0 °C(Predicted) | [density ]
1.615±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.95±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC50 of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC50 of 14 μM)[1]. | [References]
[1] Holger Steuber, et al. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. J Mol Biol. 2008 Jun 20;379(5):991-1016. DOI:10.1016/j.jmb.2008.03.063 |
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