| Chemical Properties | Back Directory | [Boiling point ]
352.3±27.0 °C(Predicted) | [density ]
1.149±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 18 mg/mL | [form ]
solid | [pka]
3.19±0.10(Predicted) | [color ]
off-white |
| Hazard Information | Back Directory | [Uses]
SC-68376 is a potent, reversible, ATP-competitive, and selective inhibitor of p38 MAP kinase inhibitor[1][2][3]. | [Definition]
ChEBI: 2-methyl-4-phenyl-5-pyridin-4-yloxazole is a member of 1,3-oxazoles. | [References]
[1] H. Bosch, et al. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors. US20030181411A1. 2005-12-07.
[2] Ermert M, et al. Cyclooxygenase-2-dependent and thromboxane-dependent vascular and bronchial responses are regulated via p38 mitogen-activated protein kinase in control and endotoxin-primed rat lungs. Lab Invest. 2003;83(3):333-347. DOI:10.1097/01.lab.0000059924.47118.88
[3] Kooijman R, et al. IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase. Cell Signal. 2003;15(12):1091-1098. DOI:10.1016/s0898-6568(03)00069-x |
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