| Identification | Back Directory | [Name]
D13 | [CAS]
321945-27-1 | [Synonyms]
D13
D13,D-13
(E)-4-bromo-N'-(3,5-dibromo-2-hydroxybenzylidene)benzohydrazide | [Molecular Formula]
C14H9Br3N2O2 | [MOL File]
321945-27-1.mol | [Molecular Weight]
476.95 |
| Chemical Properties | Back Directory | [density ]
1.96±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
6.03±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. | [Uses]
D13, an Acylhydrazones derivative, possesses antifungal activity. D13 is effective against murine sporotrichosis[1]. | [References]
1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids Antimicrob. Agents Chemother. 62(5),e00156-00118(2018). |
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