| Identification | More | [Name]
SALICYLIDENE SALICYLHYDRAZIDE | [CAS]
3232-36-8 | [Synonyms]
2-HYDROXYBENZYLIDENE 2-HYDROXYBENZHYDRAZIDE
2-HYDROXYBENZYLIDENE SALICYLHYDRAZIDE
NSC 87864
SALICYLIDENE SALICYLHYDRAZIDE
SALICYLIDENE SALICYLHYDRAZONE
SCS
TIMTEC-BB SBB007781
2-hydroxy-benzoicaci[(2-hydroxyphenyl)methylene]hydrazide
(2-hydroxybenzylidene)salicylohydrazide
Salicylidenesalicylhydrazide,97%
2-Hydroxybenzylidene 2-hydroxybenzhydrazide, NSC 87864, SCS
(2-Hydroxyphenyl)[2-(2-hydroxybenzylidene)hydrazono]methanol
1-(2-Hydroxybenzoyl)-2-(2-hydroxybenzylidene)hydrazine
1-Salicylidene-2-salicyloylhydrazine
1-Salicyloyl-2-salicylidenehydrazine
N'-(2-Hydroxybenzylidene)-2-hydroxybenzhydrazide
N'-Salicylidenesalicylic hydrazide | [EINECS(EC#)]
221-773-2 | [Molecular Formula]
C14H12N2O3 | [MDL Number]
MFCD00043494 | [Molecular Weight]
256.26 | [MOL File]
3232-36-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29280000 |
| Hazard Information | Back Directory | [Uses]
SCS is a selective inhibitor of β1-containing GABAA receptors. | [Definition]
ChEBI: 2-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]benzohydrazide is a member of salicylamides. | [Biological Activity]
Potent and selective partial inhibitor of β 1-containing GABA A receptors (IC 50 values are 4.5, 5.3 and 7.9 nM at α 2 β 1 γ 1 θ , α 2 β 1 γ 1 and α 2 β 1 γ 2s GABA A receptors respectively). May bind allosterically to a novel site on GABA A receptor. | [in vivo]
SCS (Salicylidene salicylhydrazide; 500-1000 mg/kg, i.p. or 800-1000 mg/kg, oral) produces abdominal constrictions in mice[2].
SCS (10-75 mg/kg; i.p.; once) shows antinociceptive activity against tonic, phasic and Capsaicin (HY-10448) nociception in mice[2].
SCS (10-75 mg/kg; i.p.; once) shows anti-inflammatory activity in mice[2].
SCS (50 and 75 mg/kg; i.p.; once) shows antinociceptive activity against neuropathic nociception[2].
| Animal Model: | BALB/c mice; tonic, phasic and Capsaicin (HY-10448) nociception model[2] | | Dosage: | 10, 25, 50, and 75 mg/kg | | Administration: | IP, single dose | | Result: | Produced a significant protection on tonic, phasic and capsaicin nociception in a dose-dependent manner. |
| Animal Model: | BALB/c mice, Oxaliplatin (HY-17371)-induced neuropathic nociception model[2] | | Dosage: | 50 and 75 mg/kg | | Administration: | IP, single dose | | Result: | Significantly attenuated the paw withdrawal threshold changes associated with Oxaliplatin. Significantly increased the percent antinociception during 30-120 min.
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| [storage]
Store at RT |
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