| Identification | Back Directory | [Name]
4-[(AMinocarbonyl)aMino]-N-[(9H-fluoren-9-ylMethoxy)carbonyl]-D-phenylalanine | [CAS]
324017-22-3 | [Synonyms]
Fmoc-D-4-Aph(cbm)
Fmoc-4-Aph(Trt)-OH
Fmoc-D-Aph(Cbm)-OH
FMoc-D-4-Aph(CbM)-OH
(9H-Fluoren-9-yl)MethOxy]Carbonyl D-Aph(Cbm)-OH
4-[(AMinocarbonyl)aMino]-N-[(9H-fluoren-9-ylMethoxy)carbonyl]-D-phenylalanine
D-Phenylalanine, 4-[(aminocarbonyl)amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-ureidophenyl)propanoic acid
(2R)-3-[4-(carbamoylamino)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid | [Molecular Formula]
C25H23N3O5 | [MDL Number]
MFCD26743751 | [MOL File]
324017-22-3.mol | [Molecular Weight]
445.47 |
| Chemical Properties | Back Directory | [Melting point ]
163℃ (decomposition) | [Boiling point ]
699.1±55.0 °C(Predicted) | [density ]
1.376±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
3.82±0.10(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic | [InChIKey]
HFPDOFBZCSQAEJ-JOCHJYFZSA-N | [SMILES]
C(O)(=O)[C@@H](CC1=CC=C(NC(N)=O)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| Hazard Information | Back Directory | [Uses]
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity[1]. | [References]
[1] Guangcheng Jiang, et al. "GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6." Journal of medicinal chemistry 44.3 (2001): 453-467. DOI:10.1021/jm0003900 |
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