| Identification | Back Directory | [Name]
Benzenesulfonamide, N-[(1-cyano-3-azetidinyl)methyl]- | [CAS]
325775-42-6 | [Synonyms]
NAAA-IN-2
Benzenesulfonamide, N-[(1-cyano-3-azetidinyl)methyl]- | [Molecular Formula]
C11H13N3O2S | [MOL File]
325775-42-6.mol | [Molecular Weight]
251.3 |
| Chemical Properties | Back Directory | [Boiling point ]
481.9±37.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.11±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Cathepsin K inhibitor 6 (compound 19) is an inhibitor of cathepsin K (Cat K) with an IC50 of 17 nM. Cathepsin K inhibitor 6 also has inhibitory effects on other isoforms, with IC50s of 0.05 μM (Cat L) and 0.3 μM (Cat B), respectively[1]. | [IC 50]
cathepsin L: 0.05 μM (IC50); Cathepsin B: 0.3 μM (IC50); cathepsin K: 17 nM (IC50) | [References]
[1] Falgueyret JP, et al. Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. J Med Chem. 2001 Jan 4;44(1):94-104. DOI:10.1021/jm0003440 |
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